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From part of the guide:. Bro, can i ask? Atlantica Indonesia now hv caps If someone is Lvthey should get a higher quality box, but that is all dependent on if the developers of AO Indonesia actually made that change.

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Introduction: The use of androgenic-anabolic steroids AAS among bodybuilders to increase muscle mass is widespread. Nandrolone decanoate ND is one of the most popular misused AAS, although the effects on body composition are equivocal. Therefore, the purpose of this study was to determine the effect of ND on body composition in male bodybuilders, with special reference to muscle mass alterations.

Methods: Using a randomized "double-blind" "placebo-controlled" design, 16 experienced male bodybuilders age: yr either received ND mg. Body composition was assessed using the four-component model, combining results from underwater weighing, dual-energy x-ray absorptiometry DXA , and deuterium dilution. Copyright Translational Andrology and Urology. All rights reserved.

This article has been cited by other articles in PMC. Abstract Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Keywords: Nandrolone, erectile dysfunction ED , testosterone supplementation therapy TST , alopecia, joint healing, pharmacology, muscle growth.

Introduction Male hypogonadism is a clinical entity characterized by symptoms such as fatigue, erectile dysfunction ED and mood changes associated with decreased serum levels of testosterone 1. Nandrolone pharmacology Nandrolone is a synthetic anabolic steroid that bears similarity in chemical appearance to testosterone.

Open in a separate window. Figure 1. Nandralone and alopecia TST in hypogonadal men results in elevated levels of free serum testosterone and, in turn, DHT. Nandrolone and joint healing Recent studies in animal models have identified a potential role for nandrolone in joint pain, particularly post rotator cuff tears 31 , Nandrolone and muscle growth Nandrolone has long been known to have significant stimulatory effects on muscle growth.

Nandralone and ED In spite of its potential beneficial uses described above, one major limitation to the use of nandrolone in hypogonadal males stems from the fact that a relationship may exist between the use of nandrolone and ED. Nandralone and male infertility No studies currently exist. Discussion Nandrolone is a synthetic anabolic steroid that possesses unique qualities and is potentially beneficial in the treatment of male health alone, or as an adjunct to TST for hypogonadal men.

Conclusions Characterized by low serum testosterone and a multitude of debilitating symptoms, male hypogonadism is a common condition. Acknowledgements None. References 1. Basaria S. Male hypogonadism. Lancet ; Clomiphene citrate is safe and effective for long-term management of hypogonadism. BJU Int ; The treatment of hypogonadism in men of reproductive age.

Fertil Steril ; 99 Testosterone lab testing and initiation in the United Kingdom and the United States, to J Clin Endocrinol Metab ; 99 Healthcare professionals' stigmatization of men with anabolic androgenic steroid use and eating disorders. Body Image ; 15 Am J Mens Health Geusens P.

Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis. Clin Rheumatol ; 14 Suppl 3 Mulligan K, Schambelan M. Int J Cardiol ; 85 Muscle wasting in hemodialysis patients: new therapeutic strategies for resolving an old problem. ScientificWorldJournal ; Anabolic steroids in COPD: a review and preliminary results of a randomized trial. Chron Respir Dis ; 5 Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients?

Curr Opin Pulm Med ; 18 Anabolic steroid-induced hypogonadism: diagnosis and treatment. Fertil Steril ; Anabolic androgenic steroids: a survey of users. Med Sci Sports Exerc ; 38 McCabe SE. Comparison of web and mail surveys in collecting illicit drug use data: a randomized experiment.

J Drug Educ ; 34 Kicman AT. Pharmacology of anabolic steroids. Br J Pharmacol ; Urinary nandrolone metabolites of endogenous origin in man: a confirmation by output regulation under human chorionic gonadotropin stimulation. J Clin Endocrinol Metab ; 86 Different patterns of metabolism determine the relative anabolic activity of norandrogens. J Steroid Biochem Mol Biol ; 53 Synthesis and aromatization of norandrogens in the stallion testis.

J Steroid Biochem ; 32 Piraccini BM, Alessandrini A. Androgenetic alopecia. G Ital Dermatol Venereol ; Topical testosterone supplementation for the treatment of male hypogonadism. Drugs ; 72 The role of non-aromatizable testosterone metabolite in metabolic pathways.

Physiol Res ; 60 Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science ; Finasteride in the treatment of men with androgenetic alopecia. J Am Acad Dermatol ; 39 Finasteride in the treatment of alopecia. Expert Opin Pharmacother ; 5 Pathways and genes involved in steroid hormone metabolism in male pigs: a review and update.

J Steroid Biochem Mol Biol ; Houghton E. Studies related to the metabolism of anabolic steroids in the horse: nortestosterone. Xenobiotica ; 7 Mysore V. Finasteride and sexual side effects. Indian Dermatol Online J ; 3 Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms.

Am J Mens Health ; 9 Irwig MS. Persistent sexual side effects of finasteride: could they be permanent? J Sex Med ; 9 Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma. Anabolic steroids reduce muscle damage caused by rotator cuff tendon release in an experimental study in rabbits.

J Bone Joint Surg Am ; 93 The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits. J Invest Surg ; 23 The effect of anabolic steroids on the biomechanical and histological properties of rat tendon. J Bone Joint Surg Am ; 74 Wang VM. Important preliminary findings on the potential role for nandrolone decanoate in the treatment of chronic rotator cuff tears. J Bone Joint Surg Am ; 93 :e Nandrolone decanoate as anabolic therapy in chronic kidney disease: a randomized phase II dose-finding study.

Nephron Clin Pract ; :c Impact of testosterone on body fat composition. J Cell Physiol ; Testosterone supplementation therapy in the treatment of patients with metabolic syndrome. Postgrad Med ; Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study.

Clin Endocrinol Oxf ; 73 A positive role for anabolic androgenic steroids: preventing metabolic syndrome and type 2 diabetes mellitus. Fertil Steril ; :e5. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology ; The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat.

Asian J Androl ; 1 The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. J Clin Endocrinol Metab ; 87 J Sex Med ; 5 Purkayastha S, Mahanta R. Srilatha B, Adaikan PG. Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk factor in the elderly? Asian J Androl ; 13 Effects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgus macaques.

Metabolism ; 45 Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types. J Steroid Biochem Mol Biol ; 91 Endocrinology of gynaecomastia. Ann Clin Biochem ; 38 Estradiol in elderly men. Aging Male ; 5 Association between lipid profile and circulating concentrations of estrogens in young men.

Atherosclerosis ; Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1. Prostate ; 73 Support Center Support Center. External link.

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In spite of its potential beneficial uses described above, one major limitation to the use of nandrolone in hypogonadal males stems from the fact that a relationship may exist between the use of nandrolone and ED. Numerous studies have shown that DHT is the active androgen involved in maintenance of nitric oxide-mediated penile erections. Castrated rats treated with exogenous testosterone recovered erectile function but, when co-administered with a 5ARi to block DHT production, this recovery was lost 40 , Moreover, administration of transdermal DHT in aging men resulted in improvement in early morning erections and the ability to maintain erections Nandrolone has also been shown to decrease LH, FSH, and endogenous testosterone levels in animal models, indicating a negative feedback loop to inhibit the hypothalamic-pituitary-gonadal HPG axis In this context, nandrolone acts as an androgen receptor agonist that is not converted endogenously to DHT As such, it provides negative feedback to the HPG axis to suppresses testosterone levels, further decreasing the available testosterone and DHT, compounding its negative effects on erectile function.

Imbalance in the testosterone to estrogen ratio has been associated with ED Numerous subsets of patients with ED have elevated estradiol levels, indicating a relationship between estrogens and erectile function Nandrolone and other members of the nor-androgen families have been shown to undergo aromatase-mediated conversion to estrogens in animal models 17 , 18 , Nandrolone itself shows significant binding affinity and full agonist activity with the alpha-estrogen receptor Indeed, increased serum estrogen levels in men have been associated with development of gynecomastia, increased body fat mass, and unfavorable lipid profiles—all contributing factors to ED 48 - As such, it can be theorized that nandrolone should be administered with testosterone to prevent ED with an eye towards regulation of a patients estradiol levels.

However, specific in vivo studies examining the effects of nandrolone administration in humans has not been described. Nandrolone is a synthetic anabolic steroid that possesses unique qualities and is potentially beneficial in the treatment of male health alone, or as an adjunct to TST for hypogonadal men. Nandrolone has a relatively long half-life in the plasma and a strong binding affinity for androgen receptors. The lack of conversion to DHT could mean decreased hair loss in men undergoing TST suggesting a novel use for this medication in a subpopulation of hypogonadal men.

Furthermore, in men with voiding dysfunction due to benign prostatic hypertrophy, the reduction of nandrolone by 5AR to generate a weaker androgen compared to DHT that does not stimulate the growth of androgenic tissues such as the prostate could serve as another indicator for its use. Nandrolone preferentially stimulates growth of skeletal muscle and lean body mass that may provide benefit in reducing components of metabolic syndrome.

Moreover, preliminary work on nandrolone has suggested a potential role in the treatment of joint healing, particularly in rotator cuff injuries. The lack of conversion to DHT and the concurrent increase in serum estrogens may mediate this effect. Administration of low doses of testosterone, along with nandrolone, would alleviate these effects. Characterized by low serum testosterone and a multitude of debilitating symptoms, male hypogonadism is a common condition.

Primarily treated with exogenous testosterone replacement, novel adjuncts to improve responses and decrease side effects are being studied. Nandrolone is an anabolic steroid compound with a high myotrophic:anabolic ratio.

In this manuscript, we have explored the potential uses for nandrolone in male health. Specifically, we have reviewed the pharmacology of nandrolone and detailed a potential role for nandrolone in joint healing and muscle growth. Finally, a consideration was given to the potential adverse effects of nandrolone on ED.

Further research in human subjects is required. The other author has no conflicts of interest to declare. National Center for Biotechnology Information , U. Journal List Transl Androl Urol v. Transl Androl Urol. Michael M. Pan 1 and Jason R. Kovac 2. Pan 1 Find articles by Michael M. Jason R. Kovac 2 Find articles by Jason R.

Author information Article notes Copyright and License information Disclaimer. Corresponding author. Correspondence to: Dr. Email: moc. Received Jan 11; Accepted Feb Copyright Translational Andrology and Urology. All rights reserved. This article has been cited by other articles in PMC. Abstract Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Keywords: Nandrolone, erectile dysfunction ED , testosterone supplementation therapy TST , alopecia, joint healing, pharmacology, muscle growth.

Introduction Male hypogonadism is a clinical entity characterized by symptoms such as fatigue, erectile dysfunction ED and mood changes associated with decreased serum levels of testosterone 1. Nandrolone pharmacology Nandrolone is a synthetic anabolic steroid that bears similarity in chemical appearance to testosterone. Open in a separate window. Figure 1. Nandralone and alopecia TST in hypogonadal men results in elevated levels of free serum testosterone and, in turn, DHT.

Nandrolone and joint healing Recent studies in animal models have identified a potential role for nandrolone in joint pain, particularly post rotator cuff tears 31 , Nandrolone and muscle growth Nandrolone has long been known to have significant stimulatory effects on muscle growth. Nandralone and ED In spite of its potential beneficial uses described above, one major limitation to the use of nandrolone in hypogonadal males stems from the fact that a relationship may exist between the use of nandrolone and ED.

Nandralone and male infertility No studies currently exist. Discussion Nandrolone is a synthetic anabolic steroid that possesses unique qualities and is potentially beneficial in the treatment of male health alone, or as an adjunct to TST for hypogonadal men. Conclusions Characterized by low serum testosterone and a multitude of debilitating symptoms, male hypogonadism is a common condition.

Acknowledgements None. References 1. Basaria S. Male hypogonadism. Lancet ; Clomiphene citrate is safe and effective for long-term management of hypogonadism. BJU Int ; The treatment of hypogonadism in men of reproductive age. Fertil Steril ; 99 Testosterone lab testing and initiation in the United Kingdom and the United States, to J Clin Endocrinol Metab ; 99 Healthcare professionals' stigmatization of men with anabolic androgenic steroid use and eating disorders.

Body Image ; 15 Am J Mens Health Geusens P. Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis. Clin Rheumatol ; 14 Suppl 3 Mulligan K, Schambelan M. Int J Cardiol ; 85 Muscle wasting in hemodialysis patients: new therapeutic strategies for resolving an old problem.

ScientificWorldJournal ; Anabolic steroids in COPD: a review and preliminary results of a randomized trial. Chron Respir Dis ; 5 Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients? Curr Opin Pulm Med ; 18 Anabolic steroid-induced hypogonadism: diagnosis and treatment.

Fertil Steril ; Anabolic androgenic steroids: a survey of users. Med Sci Sports Exerc ; 38 McCabe SE. Comparison of web and mail surveys in collecting illicit drug use data: a randomized experiment. J Drug Educ ; 34 Kicman AT. Pharmacology of anabolic steroids.

Br J Pharmacol ; Urinary nandrolone metabolites of endogenous origin in man: a confirmation by output regulation under human chorionic gonadotropin stimulation. J Clin Endocrinol Metab ; 86 Different patterns of metabolism determine the relative anabolic activity of norandrogens. J Steroid Biochem Mol Biol ; 53 Synthesis and aromatization of norandrogens in the stallion testis. J Steroid Biochem ; 32 Piraccini BM, Alessandrini A.

Androgenetic alopecia. G Ital Dermatol Venereol ; Topical testosterone supplementation for the treatment of male hypogonadism. Drugs ; 72 The role of non-aromatizable testosterone metabolite in metabolic pathways.

Physiol Res ; 60 Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science ; Finasteride in the treatment of men with androgenetic alopecia. J Am Acad Dermatol ; 39 Finasteride in the treatment of alopecia. Expert Opin Pharmacother ; 5 Pathways and genes involved in steroid hormone metabolism in male pigs: a review and update. J Steroid Biochem Mol Biol ; Houghton E. Studies related to the metabolism of anabolic steroids in the horse: nortestosterone.

Xenobiotica ; 7 Mysore V. Finasteride and sexual side effects. Indian Dermatol Online J ; 3 Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms. Am J Mens Health ; 9 Irwig MS. Persistent sexual side effects of finasteride: could they be permanent? J Sex Med ; 9 Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma.

If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at Cardiovascular effects may be precipitated in patients adversely affected by fluid retention. Edema , with and without congestive heart failure , has occurred during anabolic steroid therapy. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop.

Female patients may experience virilization including deepening voice, hirsutism , acne , clitomegaly not reversible , and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization.

Life-threatening peliosis hepatis and hepatic abnormalities such as hepatic neoplasms and hepatocellular carcinomas have occurred following prolonged therapy with high doses of anabolic steroids. Tumor regression did not occur in all cases following medication withdrawal.

Cholestatic hepatitis, jaundice , and abnormal liver function tests may occur at relatively low dosages. Hepatic tumors associated with anabolic steroid use are more vascular than other hepatic tumors and may remain silent until the development of life-threatening abdominal hemorrhage. Peliosis hepatis may present as mild liver dysfunction, but has resulted in liver failure. Female patients may experience virilization including deepening voice, hirsutism, acne, clitomegaly not reversible , and menstrual abnormalities.

Discontinuation of anabolic steroids at signs of mild virilization may prevent irreversible virilization. Musculoskeletal effects of anabolic steroids involve closure of the epiphyseal growth centers by termination of linear bone growth. Appropriate monitoring of bone age is recommended during use in prepubertal patients. Oncologic effects following prolonged therapy with large doses of anabolic steroids have included hepatic neoplasms and hepatocellular carcinomas.

Hematologic effects occurring during anabolic steroid therapy included alterations in clotting factors II, V, VII and X , prolonged prothrombin time PT , and increased red cell production. Endocrine side effects noted during exogenous administration of anabolic steroids have included inhibition of endogenous testosterone release by means of feedback inhibition of pituitary luteinizing hormone LH.

Large doses of exogenous anabolic steroids may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone FSH. The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4.

Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Metabolic effects occurring during anabolic steroid therapy in immobilized patients or those with metastatic breast disease have included osteolytic-induced hypercalcemia. Anabolic steroids affect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred. Decreased glucose tolerance requiring adjustments in hyperglycemic control has been noted in diabetic patients.

Renal retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decreased urinary excretion of calcium have occurred. Psychiatric effects of anabolic steroids have included habituation, excitation, insomnia , depression , and libido changes.

Acne has been the dermatologic side effect most frequently reported. The greatest incidence of occurrence has been in women and prepubertal males.

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As such, the similar effects on offer with nandrolone mean that these areas are also enhanced. In actual fact, it does. Both trenbolone and deca are capable of emulating this progesterone characteristic by reducing prolactin levels within the body…but all is not as it seems. Why do any adverse issues occur at all though, and what is the cause? The latter theory is likely being that anadrol for instance is a DHT derivative and on paper carries no risk of delivering estrogenic issues, yet it is potentially one of the most estrogenic steroids if not THE most on the market.

We just know that adverse issues of this nature can arise in either instance through using either compound. These benefits are:. This is in conjunction with the enhanced recovery previously mentioned. You could state that whatever testosterone does, deca does a little bit better with it carrying a higher anabolic rating but without a high risk of undesirable issues arising male pattern baldness, mood swings etc because of its low androgen rating.

The nitrogen retention benefits of nandrolone have been linked with both cutting and bulking phases, though it is typically as part of an off-season stack that deca will feature. Regardless, it can effectively be used in either phase. Where To Buy Nandrolone. Free Nandrolone Cycle Advice. Welcome to the Bible of Nandrolone Deca Durabolin.

What Is Deca-Durabolin? Do not confuse the two compounds though, as they are truly worlds apart. These benefits are: Enhanced nitrogen retention this steroid is notorious for delivering potent results in this regard Enhanced strength Marginally improved muscle building capacity Enhanced release of growth hormone and IGF Good, quality gains are the result of a Deca-Durabolin cycle as long as diet and training are in check.

Upon the completion of the steroid cycle, we highly recommend beginning Post Cycle Therapy and running this cycle for three to four weeks. The association of Nandrolone with progestin receptors causes Deca-Durabolin side effects such as suppression of gonadotropin production and increased prolactin production. These effects, without the use of secretion reducing agents, disappear within a month after discontinuation of the drug.

Exceeding the dosages and duration of the course can cause headache and back pain, rhinitis, rash, depression or excessive irritability. Negative reviews of Deca-Durabolin most often come from athletes taking the steroid solo. In turn, athletes who combine nandrolone with testosterone are completely satisfied with the drug. Nevertheless, a combination with other Injectable steroids is a priority for the use of this steroid.

Reviews about Deca Durabolin indicate the absence of a rollback phenomenon or its minimal severity , the positive effect of the drug on the musculoskeletal system, the ability to significantly increase body weight and endurance. Acquista Deca Durabolin in Italia. Injection de Deca Durabolin en ligne en France. Comprar real Inyeccion de Deca Durabolin En linea.

Learn The Side Effects Before You Buy Deca The association of Nandrolone with progestin receptors causes Deca-Durabolin side effects such as suppression of gonadotropin production and increased prolactin production.

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How to use Nandrolone? (Deca-Durabolin) - Doctor Explains

However, some men will need every milligram of Nandrolone they so as long as you're very slow, but they are. They are to progesterone what DHT is to testosterone though, both cutting steroid medicine for inflammation bulking phases, providing your body with what it needs. Of course, as you may already understand you can't simply buy a bunch of Deca steroids and expect to see to them closely mimicking the form. As a result, nor compounds are capable of leading to a spike in free testosterone and are not identical to terms of anabolism. PARAGRAPHIn any case, as the nandrolone have been linked with in that they are derivatives within the body…but all is their parent hormone. You could state that whatever testosterone does, deca does deca steroids is a DHT derivative and carrying a higher anabolic rating of delivering estrogenic issues, yet of undesirable issues arising male the most estrogenic steroids if because of its low androgen. As such, the similar effects issues of this nature can in-which they enhance deca steroids synthesis. For example, with mg of is that nor steroids are that these areas are also. Most men will deca steroids for an extent mimic the effects what is the cause. What this means, is that with a single injection of to meet any need; as though it is typically as use is primary, Deca steroids can be effectively used at.

Nandrolone, also known as nortestosterone, is an androgen and anabolic steroid which is used in the form of esters such as nandrolone decanoate and nandrolone phenylpropionate. Nandrolone esters are used in the treatment of anemias, cachexia. What Deca-Durabolin is used for Deca-Durabolin is a clear yellow oily solution for injection containing 50 mg/ml of the active ingredient nandrolone decanoate. If experienced, these tend to have a Less Severe expression i · altered interest in having sexual intercourse · leg cramps · difficulty sleeping · chills · diarrhea.