This type of painkiller may increase the risk of side effects on the gut, such as stomach ulceration and bleeding. Remember that many cold and flu remedies and over-the-counter painkillers contain ibuprofen or aspirin and so should be avoided while you're taking prednisolone.
Be sure to check the ingredients of other medicines before taking them with prednisolone, or ask your pharmacist for advice. It's fine to take paracetamol with prednisolone. You can also take opioid-type painkillers such as codeine or co-codamol. Check with your doctor or pharmacist before using steroid creams eg for eczema or allergic skin reactions or steroid nasal sprays eg for hayfever while you're using prednisolone. Prednisolone can cause fluid and salt retention and so may oppose the effects of the following medicines:.
Prednisolone may increase blood sugar levels and so may oppose the blood sugar lowering effects of antidiabetic medicines. People with diabetes may need an increase in their dose of insulin or antidiabetic tablets. Prednisolone may enhance the anti-blood-clotting effect of anticoagulant medicines such as warfarin.
If you're taking warfarin with prednisolone your blood clotting time INR should be regularly monitored, particularly after starting or stopping treatment with prednisolone and after any dose changes. The level of potassium in your blood is more likely to fall too low if you take prednisolone with other medicines that can lower the amount of potassium in your blood, such as:. The following medicines may increase the removal of prednisolone from the body, thus reducing its effects.
You may need a larger dose of prednisolone if you are also taking any of these medicines:. The effect of corticosteroids may be reduced in the three to four days following use of mifepristone. The following medicines may reduce the removal of prednisolone from the body and so may increase its effects or side effects:. Prednisolone may weaken your immune system, which means that vaccines may be less effective if given during treatment, because your body won't produce sufficient antibodies in response to the vaccine.
Live vaccines shouldn't be given to people taking prednisolone because they may cause serious infections. Live vaccines include: measles, mumps, rubella MMR , BCG, chickenpox, oral typhoid, yellow fever and the nasal spray flu vaccine for children.
You shouldn't be given a live vaccine until at least three months after finishing your course of prednisolone. Last updated: Parenting Mental health Healthy eating Conditions Follow. Type keyword s to search. Can I take over-the-counter medicines with prednisolone? Can prednisolone affect my current medicines?
One of the side-effects of Advil and other NSAIDs is an erosion of the lining of the digestive tract, which can lead to stomach ulcers as well as bleeding in the intestines and colon. Unfortunately, prednisone in combination with these drugs dramatically increases the chance of this occurring. The most common signs of gastrointestinal GI bleeding are:.
Even though Advil and other NSAIDs are widely available and highly effective in managing symptoms, you have to be careful when taking them. Risk of GI bleeding and other side-effects is increased in several types of patients:. These are the signs you should stop taking the drug and call The idea, especially with drugs like NSAIDs and corticosteroids, is to find the smallest possible dose. In turn, you have a responsibility to yourself as a patient to be careful.
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Goldstein JL, Cryer B. Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies. Drug Healthc Patient Saf. Table of Contents View All. Table of Contents. Taking Them Together. Was this page helpful? Thanks for your feedback! Sign Up.