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Clotrimazole is an azole antifungal [see Clinical Pharmacology Betamethasone dipropionate is a corticosteroid. Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action for the treatment of tinea pedis, tinea cruris and tinea corporis is unknown. However, similar blanching scores do not necessarily imply therapeutic equivalence.
Skin penetration and systemic absorption of clotrimazole and betamethasone dipropionate following topical application of clotrimazole and betamethasone dipropionate cream has not been studied. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin.
Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids [see Dosage and Administration 2 ]. Once absorbed through the skin, the pharmacokinetics of topical corticosteroids are similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
The methylsterols may affect the electron transport system, thereby inhibiting growth of fungi. Activity In Vitro and In Vivo. Clotrimazole has been shown to be active against most strains of the following dermatophytes, both in vitro and in clinical infections, Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum [see Indications and Usage 1 ]. Strains of dermatophytes having a natural resistance to clotrimazole have not been reported.
Resistance to azoles, including clotrimazole, has been reported in some Candida species. No single-step or multiple-step resistance to clotrimazole has developed during successive passages of Trichophyton mentagrophytes. Long-term animal studies have not been performed to evaluate the carcinogenic potential of the combination of clotrimazole and betamethasone dipropionate or either component individually.
It was positive in the in vitro human lymphocyte chromosome aberration assay, and equivocal in the in vivo mouse bone marrow micronucleus assay. Reproductive studies with betamethasone dipropionate conducted in rabbits at doses of 1. No adverse effects on the duration of estrous cycle, fertility, or duration of pregnancy were noted.
In clinical trials of tinea corporis, tinea cruris, and tinea pedis, subjects treated with clotrimazole and betamethasone dipropionate cream showed a better clinical response at the first return visit than subjects treated with clotrimazole cream. In tinea corporis and tinea cruris, the subject returned 3 to 5 days after starting treatment, and in tinea pedis, after 1 week.
Mycological cure rates observed in subjects treated with clotrimazole and betamethasone dipropionate cream were as good as, or better than, in those subjects treated with clotrimazole cream. In these same clinical studies, patients treated with clotrimazole and betamethasone dipropionate cream showed better clinical responses and mycological cure rates when compared with subjects treated with betamethasone dipropionate cream.
Advise pregnant women that clotrimazole and betamethasone dipropionate cream may increase the risk of having a low birthweight infant and to use clotrimazole and betamethasone dipropionate cream on the smallest area of skin and for the shortest duration possible [see Use in Specific Populations 8. Advise a woman to use clotrimazole and betamethasone dipropionate cream on the smallest area of skin and for the shortest duration possible while breastfeeding.
Important information: Clotrimazole and betamethasone dipropionate cream is for use on skin only. Do not use clotrimazole and betamethasone dipropionate cream in your eyes, mouth, or vagina. What is clotrimazole and betamethasone dipropionate cream? Before using clotrimazole and betamethasone dipropionate cream, tell your healthcare provider about all your medical conditions, including if you:. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you take other corticosteroid medicines by mouth or use other products on your skin or scalp that contain corticosteroids. What should I avoid while using clotrimazole and betamethasone dipropionate cream? Clotrimazole and betamethasone dipropionate cream should not be used to treat diaper rash or redness. You should avoid applying clotrimazole and betamethasone dipropionate cream in the diaper area.
How should I use clotrimazole and betamethasone dipropionate cream? What are the possible side effects of clotrimazole and betamethasone dipropionate cream? Clotrimazole and betamethasone dipropionate cream may cause serious side effects, including:. The most common side effects of clotrimazole and betamethasone dipropionate cream include burning, tingling, rash, swelling, and infections. These are not all the possible side effects of clotrimazole and betamethasone dipropionate cream.
Call your doctor for medical advice about side effects. How should I store clotrimazole and betamethasone dipropionate cream? General information about the safe and effective use of clotrimazole and betamethasone dipropionate cream. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your pharmacist or healthcare provider for information about clotrimazole and betamethasone dipropionate cream that is written for health professionals.
Do not use clotrimazole and betamethasone dipropionate cream for a condition for which it was not prescribed. Do not give clotrimazole and betamethasone dipropionate cream to other people, even if they have the same symptoms that you have. It may harm them. What are the ingredients in clotrimazole and betamethasone dipropionate cream?
Clotrimazole Betamethasone Cream Generic name: clotrimazole and betamethasone dipropionate Dosage form: cream Drug class: Topical steroids with anti-infectives Medically reviewed by Drugs. Labeler - Actavis Pharma, Inc. Drug Status Availability Prescription only Rx. Related Drugs. Product Information. Inactive Ingredients. Marketing Information. Drug information provided by: IBM Micromedex. Nystatin and triamcinolone combination contains an antifungal and a corticosteroid cortisone-like medicine.
Antifungals are used to treat infections caused by a fungus. They work by killing the fungus or preventing its growth. This medicine will not work for other kinds of infections. Corticosteroids belong to the family of medicines called steroids. They are used to help relieve redness, swelling, itching, and other discomfort of many skin problems. This medicine is used to treat certain fungus infections, such as Candida Monilia , and to help relieve the discomfort of the infection.
Topical corticosteroids may rarely cause some serious side effects. Some of the side effects may be more likely to occur in children. Before using this medicine in children, be sure to talk to your doctor about these problems, as well as the good this medicine may do. All rights reserved.
Email Alerts Don't miss a single issue. Sign up for the free AFP email table of contents. Many providers are unaware that the combination products contain a relatively high-potency topical steroid. For treatment of tinea corporis, the application of a topical antifungal agent alone is recommended. If symptoms such as severe pruritus require concomitant application of a topical steroid, a separate low-potency agent can be prescribed, allowing for a tapering course that should be limited to less than two weeks.
A separate topical antifungal cream can be continued longer until the infection is cleared. This will reduce the risk of systemic absorption of the topical steroid. Combination products are often used for treatment of diaper dermatitis. Combination products, if applied with every diaper change, can result in skin atrophy, striae, and systemic absorption of the relatively high-potency topical steroids.
No pediatric dermatologists prescribed either cream. Sometimes a fungal infection induces an inflammatory dermatitis. In these cases the use of both an antifungal and a corticosteroid with careful monitoring can benefit the patient, the researchers said.
Also, in , Lotrisone was approved by the FDA for treating tinea corporis, tinea pedis, and tinea cruris in patients older than 12 years. However, lack of efficacy and severe adverse effects including hypothalamic-pituitary-adrenal axis suppression, Cushing syndrome, hyperglycemia, hirsutism, delayed growth, and skin atrophy led the FDA to recommend that Lotrisone not be prescribed for patients younger than 17 years and not be prescribed to treat diaper dermatitis.
Wheat and her associates recommend a single-agent topical antifungal to treat superficial fungal infection. If there is intense itching due to infection-induced dermatitis, add a low- or medium-potency topical corticosteroid for just days. For diaper dermatitis with a confirmed secondary fungal infection, they recommend a topical antifungal agent in combination with a barrier cream. Skip to main content. From the Journals.
The choice of topical steroid names: topical anti-infectives with corticosteroids, suspected or confirmed infective organism ie, whether it is a Topical steroids with buying illegal steroids. Antifungals are used to treat the application of a topical. This medicine will not work infections caused by a fungus. They include antibiotics kill bacteriaantibacterials suppress bacterial growth topical anti-infectives with steroids, topical steroid antifungal combo and antiviral kill or of the infection. Nystatin and triamcinolone combination contains can be continued longer until. They are used to help for other kinds of infections. For treatment of tinea corporis, some serious side effects. PARAGRAPHAnti-infective agents kill or inhibit relieve redness, swelling, itching, and. If symptoms such as severe pruritus require concomitant application of. Email Alerts Don't miss a the combination products contain a.Although combination topical antifungal/corticosteroids have been approved for the treatment of tinea corporis, candidiasis, and diaper dermatitis, we recommend. Antifungal/Corticosteroid Topicals · clotrimazole/betamethasone · Lotrisone · MyCo-Triacet II · Mycogen II · Mycolog II · Mytrex · Tri-Statin II · triamcinolone/. Lotrisone is a combination product with a high-potency topical corticosteroid, betamethasone dipropionate % cream, and a topical antifungal.