Detailed Description:. Spinal cord injury results in significant loss of muscle mass. Oxandrolone, a derivative of testosterone, is an anabolic steroid shown to promote gain in body weight and muscle mass after trauma, severe illness, surgery, burns, and stress.
To date there are no studies that have evaluated the effect of oxandrolone in persons with chronic spinal cord injury. This study will assess the effect of oxandrolone on strength, metabolic rate, lean body mass, pulmonary function, and ambulation in persons with chronic SCI.
This study has the potential to yield valuable information concerning the use of oxandrolone after SCI. Drug Information available for: Oxandrolone. FDA Resources. Arms and Interventions. Outcome Measures.
Primary Outcome Measures : Part-A: lean body mass, upper extremity muscle strength. Part-B: upper extremity strength, lean body mass, functional status, safety, quality of life, community. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. Barton RG.
Nutrition support in critical illness. Nutr Clin Pract. Nutritional and metabolic response to acute spinal-cord injury. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.
J Biol Chem. Body sodium and potassium in men with spinal cord injury. Arch Phys Med Rehabil. Circuit training provides cardiorespiratory and strength benefits in persons with paraplegia. Med Sci Sports Exerc.
Circuit resistance training in persons with complete paraplegia. Oral steroids are prescription-only medications. During your visit with your doctor, ask about the side effects and complications associated with these drugs. Also, make sure you understand exactly how to properly use your oral steroid, as it may be on a tapered schedule in contrast to a simple one-pill-per-day regimen.
Safely using your drug means using it exactly as your doctor prescribes. If you have questions about how to use your oral steroid, call your doctor or speak to your pharmacist when you pick up your prescription. Oral steroids can be an adjunct to reduce pain and inflammation from back or neck pain particularly from a pinched nerve when other treatments have failed, but it is essential to use them as your doctor orders to prevent potentially harmful side effects. If you complete your course of medication and find that, your pain is still interfering with your quality of life, talk to your doctor about other treatments such as physical therapy, spinal injections, etc.
Reference 1. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ ;j Sources Prednisone and other corticosteroids. Mayo Clinic Web site.
Who should take oral steroids, what are the risks and side effects? Written by Gerard Malanga, MD. How Oral Steroids Work Oral steroids are designed to work in the same way as the hormones produced by your adrenal glands in response to stress and injury. Oral Steroids: General Dosing Information Below are examples of oral steroids generic names are listed first, and a brand name example is in parentheses : Methylprednisolone Medrol Prednisone Deltasone Dexamethasone Decadron Oral steroids are generally prescribed for a limited time—typically 1 or 2 weeks.
For example: You might take 7 oral steroid pills on day 1, 6 pills on day 2, and so on until you reach 1 pill a day. Then, at the end of the week or second week , you take no more medication. Who Should Take Oral Steroids? Oral Steroids Strengths and Weaknesses Among the biggest benefits of oral steroids is that they offer relief from pain and inflammation without the invasiveness of their injected counterparts.
Possible side effects may include: Weight gain Elevated blood pressure Increased eye pressure glaucoma Swollen legs Psychological changes, such as mood swings, memory loss, and behavioral changes Sleep difficulties It is a long-held belief that short-term use of oral steroids provides protection against more serious side effects.
If oral steroids are required as a long-term treatment—such as in treatment of certain inflammatory disorders eg, lupus, ankylosing spondylitis —you should be aware of the following side effects that may occur with prolonged use: Slower wound healing and increased skin bruising Increased infection risk Clouding or blurred vision High blood sugar Osteoporosis and fractures Avascular necrosis of bone death of bone due to lack of blood supply Safely Using Oral Steroids for Spine Pain Oral steroids are prescription-only medications.
View Sources Reference 1.
Oral pain medications come in the form of tablets, capsules, and liquid formulations. Examples of these types of pain medications include:. See Acetaminophen for Back Pain. See Antidepressants: Definitive Guide. See Medications for Neuropathic Pain. See Opioid Pain Medications.
All medications, including over-the-counter medications, carry risks and side effects. A health care provider can help select which drugs are appropriate for a specific condition, symptom s , or type of pain. Topical pain relief medications include creams, gels, or patches applied to the skin. They are available in both over-the-counter and prescription strengths.
They are often recommended to reduce localized pain, such as from an arthritic joint or sore muscle. Pain relief medications that can be delivered topically include: Capsaicin. Pain from certain conditions, such as osteoarthritis and fibromyalgia, can be lessened with capsaicin. Capsaicin is a cream or gel made from chili peppers, and delivers a hot sensation to the area it is applied.
Capsaicin can easily be made at home using all-natural ingredients, such as cayenne powder and coconut oil. Orthopedic specialists usually offer them for shooting nerve pain sciatica from a ruptured disk, or symptoms associated with narrowing of the space around the spinal cord spinal stenosis. Even for nerve-related back pain, try the conservative route first, because steroid shots come with risks.
Conservative therapy includes the following:. How long should you wait before considering injection therapy? It depends on the intensity of the pain and how long you can bear it before it starts to ease on its own. Most men experience substantial improvement within six to eight weeks. Steroid injections contain various formulations of medications.
A common combination is a numbing drug similar to procaine Novocain mixed with the anti-inflammatory drug cortisone. Once the cortisone injection finds its target, the numbing effect will start to wear off within hours. If the cortisone shot works, you'll certainly be grateful for the relief, but success is not guaranteed. In studies of large groups of back pain sufferers, the benefit is small to none on average. It's hard to predict what you, individually, will experience.
Corticosteroid injections do not change the course of a chronic back pain condition. Months down the road, you will generally end up in the same condition as if you never got the shot. In the meantime, the shot could ease your discomfort. Harmful side effects of cortisone injections are uncommon, but they do happen.
Less commonly, the needle could injure a nerve or blood vessel. Having too many injections in the same target area can cause nearby tissues, such as joint cartilage, to break down. Corticosteroids can also cause skin at the injection site or the soft tissue beneath it to thin. This is why it's recommended to limit the number of cortisone injections to three or four per year at any body region treated.
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