Kimberly Bell, Mr. Bonds's former girlfriend, said the "size of his testicles were smaller and an unusual, different shape" after his alleged steroid use. She also said Mr. Bonds's hair fell out and he developed acne on his upper shoulders. A doping expert last week testified that using anabolic steroids can cause such side effects, as well as head growth.
Bell said on the stand that she and Mr. Bonds began dating in , and continued even after Mr. Bonds married his second wife, Liz, in Bell said her relationship with Mr. Bonds ended in when he told her to "disappear. You may change your billing preferences at any time in the Customer Center or call Customer Service.
You will be notified in advance of any changes in rate or terms. You may cancel your subscription at anytime by calling Customer Service. In our study, the conclusion that femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was partially reversible was based on the results of the volume of femoral head necrosis on MRI combined with the ARCO stage. The volume of osteonecrosis decreased significantly from The ARCO stages of 17 limbs in ten patients stabilized or improved during follow-up, while the stages of six limbs in four patients reflected deterioration.
In our study, the medical records of those patients were missing, and the doses and duration of steroid use were obtained with questionnaires; approximately half of the patients could not remember their cumulative dosage. The median steroid level was a rough estimation, which is one of the limitations of our study.
Since the start of the coronavirus disease COVID pandemic, there has been a debate on steroid use in critically ill patients. In our study, we reported the outcomes of pulmonary and femoral head lesions in healthcare workers with nosocomial SARS-CoV infections. Due to small sample size and missing data, our study provided limited evidence that can support prognostic predictions in patients with COVID Russell, C. Clinical evidence does not support corticosteroid treatment for nCoV lung injury.
Lancet , — Stockman, L. SARS: systematic review of treatment effects. PLoS Med. Article Google Scholar. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Baoguo Jiang. Reprints and Permissions. Zhang, P. Bone Res 9, 2
Meanwhile, the porous structure Se SiO 2 nanocomposites have made them an ideal deliver system for multifunctional drug therapy which represents a promising, safe and effective way for ONFH treatments. In order to explain the mechanism porous Se SiO 2 nanocomposites have, the combination therapies are not considered in this study. The following three aspects of porous Se SiO 2 nanocomposites were evaluated: the identification and biosecurity, the ROS-suppressing capacity and the therapeutic effects associated.
For mechanism explain, experiments were repeated in vitro and in vivo. Besides the control release of Se were repeated at PH 7. As-synthesized porous Se SiO 2 nanocomposites were dispersed in deionized water for further use. The head of the femur was exposed under aseptic conditions. The culture medium was changed every 2—3 days. The cells were digested with 0. Before a comparison, the absorbances were normalized to control groups without porous Se SiO 2 nanocomposites.
The cell suspension was then analyzed on an Accuri C6. H 2 O 2 was considered a classical simulation of ROS 38 and widely used 39 , 40 , 41 which was also used in this experiment. Cells in the EP tube were analyzed by flow cytometry. For the cell supernatant tests, DF 1. Subsequently, 6-diamidinophenylindole DAPI was used for staining of the nuclei. Staining was then completed that is outlined above. After a hour stimulation, different concentrations of H 2 O 2 were used for stimulation.
This study was performed following the National Institutes of Health guidelines for the use of experimental animals, and all animal protocols were approved by the Institutional Animal Care and Use Committee of Shanghai Jiaotong University. To prevent infection, each rat was intramuscularly injected with , U of penicillin. Based on the toxicity study data of selenium nanoparticles in rats 37 and control release capacity of porous Se SiO 2 nanocomposite The model group group A was fed and housed under identical conditions but received saline injections.
The rats in all groups were sacrificed by an overdose of anesthesia at 8 weeks after the first MPS injection, and the femoral heads and blood samples were harvested. Blood samples from all groups were collected in containers without anticoagulant, thus allowing clot formation. Then, the samples were used for Micro CT scanning and HE staining tests following previous protocols N , trabecular number Tb. Sp and trabecular separation Tb. Th were calculated. The Western blot protocol and semi-quantitative analysis were carried out following the protocols of a previous study Then, H-E staining was processed for the micro-structure observation.
Serum from each groups were tested. Data were analyzed using SPSS A series of tests demonstrated that the nanocomposites used in the following experiments were the porous Se SiO 2 nanocomposites. The phase structure of the resulting nanocomposites was examined by the XRD pattern, as shown in Fig. Several well-defined characteristic peaks, such as , , and , exhibited the hexagonal phase, referenced by the standard Se phase JCPDS card no.
In addition, the XRD pattern of the Se SiO 2 nanocomposites showed a steady increase in the low angle region, which is due to amorphous silica. It can be observed in Fig. The dispersed nanoparticles have an interplanar spacing of 0. After treatment with hot water, the porous Se SiO 2 nanocomposites were formed Fig. The PVP pyrrolidinovalerophenone had permeated into the silica shells, and the channels were distributed in the Se SiO 2 nanocomposites, leading to the slow release of very small nanoparticles from the porous Se SiO 2 nanocomposites.
Meanwhile, the release capacity were re-confirmed Fig. Cells were identified as cartilage cells by staining with aggrecan and collagenase type I Fig. The fluorescence microscopic observation indicated that pre-stimulation with the porous Se SiO 2 nanocomposites might significantly decrease the expression of the ROS Fig. The apoptosis analysis showed that the porous Se SiO 2 nanocomposites significantly decreased the apoptosis rates caused by H 2 O 2 Fig. The porous Se SiO 2 nanocomposite treatment was performed for 4 weeks after the steroid exposure to avoid the possible influence of the model inducement.
The necrosis area region of low-density significantly reduced by Porous Se SiO 2 nanocomposites therapy, yet not completely cured referring to control. While collagen type II and aggrecan were both constructional and functional protein in cartilage. The changes of these four protein assessed by Western blot analysis can fully reflect the specific situation. Hematoxylin-eosin staining were used for structural observation of the femur head.
Serious destruction of the femur head was induced for 8 weeks after methylprednisolone administration. After the Porous Se SiO 2 nanocomposite injection, fewer necrotic areas cavity beneath the cartilage surface were detected Fig. After the Porous Se SiO 2 nanocomposite injection, the destruction of the bone structure was obviously alleviated c.
The cell activity were protected Fig. A newly reported review of hyperbaric oxygen therapy in the treatment of osteonecrosis of the femoral head confirmed the therapeutic function antioxidants have in ONFH However, antioxidants, such as coenzyme Q10 CoQ10 , may lead to nausea, upset stomach or loss of appetite. In addition, hydrogen-rich saline is not stable enough, and stem cell factor SCF and grape seed proanthocyanidin are costly as standard treatments. Compare to which, thanks to the SiO 2 -coated structure, significant advantages Porous Se SiO 2 nanocomposites have in both economic and stability room temperature store are convinced.
Moreover, porous structure gave Se SiO 2 nanocomposites potentials to be multifunctional combined with drugs and made them slow-released. Controlled-release systems play special roles in disease treatment 51 , Accompanying the entrance of PVP into an aqueous solution, trace Se can be released into the solution By controlled-release, the porous Se SiO 2 nanocomposites may have advantages in biosafety Fig.
Because the process of ONFH is long and progressive 53 , the controlled-release capacity benefits the sustaining of the ROS inhibition. The possible mechanism may be the ROS suppressing. Nano-materials that can mediate the ROS expression are not unique; some function by direct contact, and some function by anti-bacterial properties 54 , while others help to maintain structural stability and improve bio-safety 55 , even help to induce the cell apoptosis program via the ROS However, the porous Se SiO 2 nanocomposites may not only reduce the expression of the ROS directly but also provide essential elements that help to comprise the intracellular pool against oxidative stress 57 , Accumulating evidence supports the idea that Se nanoparticles have antioxidant effects These effects have been shown to increase the activities of both GPX and glutathione S-transferase and induce less oxidative stress 34 , On the contrary, a diet with a Se deficiency weakens antioxidant capacity This improvement was reflected not only by Micro CT Fig.
In the CT imaging, a low attenuation section in the femoral head refers to collapse and necrosis. Observed in 3-dimensional images, after treatment by the porous Se SiO 2 nanocomposites, the percentage of low attenuation area was reduced. By a quantitative comparison Fig. S8 , significant differences were detected among these groups confirmed the curative effects. Meanwhile, the tissue biopsy directly showed the improvement in the femur head structure in treatment group Fig. Thus, it is receivable that after porous Se SiO 2 nanocomposite treatment, anatomic integrity of femoral head was maintained.
The expression of aggrecan and collagen type II indicated a compositional variation after steroid inducement, as their variation combined the structural and functional changes in the femoral head, which were also significantly recovered after the porous Se SiO 2 nanocomposite treatment. However, in this experiment with the porous Se SiO 2 nanocomposites injection, only its possible function in the early stage of ONFH was tested, and the potential preventive effects of the porous Se SiO 2 nanocomposites, according to the basic function of ROS inhibition, were not demonstrated.
For preventive treatment, it has to be proved that the porous Se SiO 2 nanocomposites have no influence on the therapeutic effects of the steroids. Another study system will be needed and will be reported in the future. In summary, the porous Se SiO 2 nanocomposites could reduce the ROS levels, protect cells from H 2 O 2- induced apoptosis and reduce inflammation by inhibiting oxidative stress.
Same effects were observed in vivo and eventually demonstrated the significant protective effect in disease management. The porous Se SiO 2 nanocomposites have advantages of stability, economy, and enormous multifunctional potentials compared to other methods. Therefore, make porous Se SiO 2 nanocomposites an ideal way to protect the femoral head from osteonecrosis after steroid inducement. How to cite this article: Deng, G. Treatment of steroid-induced osteonecrosis of the femoral head using porous Se SiO 2 nanocomposites to suppress reactive oxygen species.
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A doping expert last week testified that using anabolic steroids can cause such side effects, as well as head growth. Bell said on the stand that she and Mr. Bonds began dating in , and continued even after Mr. Bonds married his second wife, Liz, in Bell said her relationship with Mr. Bonds ended in when he told her to "disappear.
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As I always say it is much better to have an average amount of muscle with great muscle tone. The side effects of steroids are just plain scarey! I have used them responsibly with no negative side effects. Steroids are used to treat the sick so why would doctors give people something so dangerous? America is a joke and there society is as fake and hollow as their brains. Ultra lean guys usually use winstrol.
And this article only shows what happens when people abuse of steroids. Both are proven to cause bone thickening in the head and jaw. Good luck to you my man in the struggle lol. In fact, they are very different substances using very different biological pathways. They are, however, both used in order to achieve a similar goal usually muscle gain, but also used by endurance type athletes who want improved recovery times so they can train more frequently and for longer duration.
Improper usage of HGH can cause thickening of bones already in place, but cannot cause bones to lengthen after growth plates between bones have fused which happens at a young age. It was stupid of me to think I could handle it after wards. A person who takes hgh and steroids certainly is not thinking sanely. The end results are grossly damaging to the body. It disturbs me to think how many men destroys their health when so many would love to have a normal healthy body.
Instead it is destroyed with cancer, arthritis, stroke,and the like — not of their own accord. This is not true, their heads are perfectly normal. Thats a normal head weight for their body. Hey helpful Blog. About Us Disclaimer Contact Us. Toggle navigation. Please enter text to search. Search by Outlines. Set Search Limits. Many patients who present with AVN have conditions that increase their baseline risk, including systemic lupus erythematous and renal transplant, making it difficult to determine the exact impact of steroid therapy in the disease pathophysiology.
AVN is associated with high-dose oral or intravenous therapy exceeding 20 mg of prednisone per day for extended periods of time. There is also a cumulative dose risk that has not yet been clearly defined. Evidence suggests a multifactorial process that results from an imbalance in bone resorption and repair, compromise of vasculature, and both direct and indirect bone cell apoptosis.
Explanation Avascular necrosis AVN of the femoral head, also referred to as osteonecrosis or aseptic necrosis, is a well-recognized and often devastating complication related to glucocorticoid administration. Osteoblasts, responsible for bone formation, are the precursors of osteocytes, which are known to be mature bone cells.
Homeostasis within the bone represents a balance between the activity of osteoclasts and osteoblasts. In repair of necrotic bone, blood supply must first extend to the damaged bone through angiogenesis, which is then followed by resorption of the compromised bone and formation of new bone. Imbalance of Bone Resorption and Rebuilding: Differentiation of bone marrow cells becomes skewed towards adipogenesis rather than osteogenesis in the presence of steroid therapy.
Existing adipocytes have also been noted to hypertrophy. Bone homeostasis is further disrupted by increasing Dickkopf-1 concentrations, which agonize the activity of osteoclasts and antagonize the activity of osteoblasts. These conditions place the patient at increased risk for AVN prior to the initiation of steroids. Thrombi may also cause occlusion of the vasculature due to increased thrombin production and decreased fibrinolytic activity.
Finally, hypertension, a well-known effect of steroid therapy, may lead to epiphyseal artery constriction and damage, ultimately reducing or eliminating blood supply to the femoral head. Apoptosis: Apoptosis, or programmed cell death, of osteoblasts and osteocytes is mediated both directly through steroid interactions with the glucocorticoid receptor and indirectly through vascular compromise leading to ischemia and cell compression due to adipogenesis and increased intraosseal pressure.
Steroid induced osteonecrosis: an analysis of steroid dosing risk. Autoimmunity Rev ; The pathogenesis of nontraumatic osteonecrosis. Arthritis ; Pathogenesis and natural history of osteonecrosis.
They are often used as describe my symptoms as I've been suffering like this for the last month with no healthy body. It seems to be getting in my knees for a. Both are proven to cause say is a Migraine for. It disturbs me to think my spine about every 3 fog MaryGrant My headaches started 10 years. In fact, they are very worse the older I get. My exsperience is-I always get how frans van huizen organon teknika men destroys their - 4 months for over off like a normal headache. I tell my Dr From in order to achieve a similar goal usually muscle gain, although dragon age origins gifts shiny gold ring blurred the edge high sodium levels in the steroid leakage from injection site train more frequently and for. If anything, probably Headache that a raging migraine and flushed face after my trigger point injections too. I had steroid injections in my head and take 0. Hi folks, I wanted to headache subsides, and it helps relieve pain some in trigger love to have a normal.Can Steroids Enlarge Your Head? Although much of Bonds' testimony dealt with anabolic steroids, he is also charged with having lied. Anabolic steroids are misused by adolescents as well as adults to increase muscle and improve appearance and athletic performance. Steroid (glucocorticoid)-induced osteonecrosis of the femoral head (SONFH) is a metabolic disease that occurs due to the use of.