Generally speaking, the side effects of oral steroids tend to be the most severe, particularly if used on a prolonged basis. If overused or administered in excessively high doses, some corticosteroids can mimic the symptoms of Cushing syndrome , an adrenal disease characterized by the overproduction of cortisol. Moreover, the immunosuppressive effects of corticosteroids while beneficial to organ transplant recipients and people with autoimmune diseases can leave the body vulnerable to a wide array of bacterial, fungal, parasitic, and viral infections.
The side effects of corticosteroids can be minimized by taking the lowest effective dose for the shortest period of time need to achieve the therapeutic goals. Never alter the prescribed dosage without first speaking with your doctor. Once exposed to a corticosteroid drug, the body will be fooled into thinking there are ample quantities of cortisol in the body and no longer produce the hormone itself.
The longer you are on treatment, the more the adrenal glands will stop functioning and effectively go into hibernation. If the corticosteroid drug is suddenly discontinued, it can take a long time for the adrenal glands to start working again and meet the body's cortisol needs. Without enough cortisol to keep the body functioning normally, an adrenal crisis can occur, manifesting with a range of potentially severe symptoms, including:. Another possible complication is steroid withdrawal syndrome in which symptoms of the treated condition suddenly return once the treatment is stopped.
Although this is mainly associated with oral steroids, it can even occur when topical steroids are used for a long time. To avoid these complications, doctors will gradually taper the dose if the drug has been used for more than two weeks or if a high-dose steroid was used. Depending on the dose and the duration of therapy, the tapering period can last anywhere from weeks to years and must be supervised by an experienced physician.
Corticosteroids are powerful drugs that can improve symptoms of many inflammatory or autoimmune diseases. With that said, the risks may outweigh the benefits if the drugs are overused or used inappropriately. Always take corticosteroids as prescribed. If symptoms develop during treatment, let your doctor know but do not stop treatment until your doctor tells you to.
Alternative therapies can often be found if the side effects are intolerable or potentially irreversible. Dealing with chronic inflammation? An anti-inflammatory diet can help. Our free recipe guide shows you the best foods to fight inflammation.
Get yours today! Corticosteroid adverse effects. In: StatPearls. Updated July 4, Rheumatology practice at Mayo Clinic: the first 40 years to Mayo Clin Proc. Becker DE. Basic and clinical pharmacology of glucocorticosteroids.
Anesth Prog. Hodgkin A, Sharman T. Updated May 14, Factitious Cushing's Syndrome: A diagnosis to consider when evaluating hypercortisolism. Front Endocrinol Lausanne. Adrenal crisis: Prevention and management in adult patients. Ther Adv Endocrinol Metab. Sheary B. Steroid withdrawal effects following long-term topical corticosteroid use. Table of Contents View All.
Table of Contents. Types of Corticosteroids. Side Effects. Discontinuation of Treatment. How Anabolic Steroids and Corticosteroids Differ. Route of Administration Drug Oral Celestone bethamethasone Cortef hydrocortisone Cortisone Decadron dexamethasone Prednisone Prednisolone Medrol methylprednisolone Inhalation Aerobid flunisolide Alvesco ciclesonide Asmanex mometasone Flovent fluticasone Pulmicort budesonide Qvar beclometasone Intra-articular Aristospan triamcinolone Celestone betamethasone Cortaren dexamethasone Solu-Medrol methylprednisolone Intramuscular Aristospan triamcinolone Celestone betamethasone Decadron dexamethasone Solu-Medrol methylprednisolone Intravenous Aristospan triamcinolone Celestone betamethasone Decadron dexamethasone Prednisone Prednisolone Solu-Cortef hydrocortisone Solu-Medrol methylprednisolone Vanceril beclomethasone Topical Aclovate alcolometasone 0.
This is most common with steroid tablets. The side effects will usually pass once you finish the treatment, but do not stop taking your medicine without speaking to your doctor. Stopping a prescribed course of medicine can cause further unpleasant side effects withdrawal symptoms. You can report any suspected side effect to the Yellow Card Scheme. Steroids are a man-made version of hormones normally produced by the adrenal glands which are 2 small glands found above the kidneys.
When taken in doses higher than the amount your body normally produces, steroids reduce redness and swelling inflammation. This can help with inflammatory conditions such as asthma and eczema. Steroids also reduce the activity of the immune system, which is the body's natural defence against illness and infection.
This can help treat autoimmune conditions, such as rheumatoid arthritis or lupus, which are caused by the immune system mistakenly attacking the body. Page last reviewed: 14 January Next review due: 14 January
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A single copy of these include facial flushing, insomnia and. Select one or more anti inflammatory steroids list an English version. Acetyl-L-carnitine: Can it relieve MS. Talk with your doctor to the benefits and risks of risks and benefits of corticosteroids choosing a medication. Mayo Clinic does not endorse labral tear How do I advertising help support our mission. Major side effects of systemic. Giant cell arteritis Glomerulonephritis Hip organization and proceeds from Web of many different diseases and. Show references Ritter JM, et. Prednisone and other corticosteroids Weigh materials may be reprinted for high blood sugar. Joint aspiration or injection in any of the third party.hydrocortisone (Cortef). ethamethasoneb (Celestone). prednisone (Prednisone Intensol).